Drug Trials are getting impossible to find, so I have put some energy into finding medication and supplements that are already on the market and show great results:
Check these two companies out, I have personally ordereDAapproved.com
If you are here as a result of the article about the cure for Alzheimer’s, and looking for the other sites that list drug trials, please be patient, I have to look them up again. In the meantime, feel free to fill out the inquiry form just below, thanks DV
Current Alzheimer Research
Dimebon
This one is getting all the “Press” right now, it seems everybody knows about it and so far it has promising results. Used as an antihistamine in Russia for many years, it also protects against brain cell death. Dimebon targets mitochondria (the cell’s power generator). Phase 3 results show significant improvement in all the key aspects of Alzheimer’s, including thinking, memory, behavior and overall function. Results have been published in “Lancet” July 2008 (Lancet in England is the equivalent of the New England Journal of Medicine in the U.S.). Rumor is Dimebon may be on the market as soon as next year.
Rember (Methylthioninium chloride)
Early research is promising, as researchers announced that the compound appears to slow and even halt the progress of Alzheimer’s. It does this by dissolving tangles of tau protein inside brain cells and preventing their accumulation, stabilizing the disease progression in patients with mild and moderate Alzheimer’s over a period of one year. Over a longer period of 19 months, researchers saw an 81% slowing of the disease. Rember may be on the market as early as 2012.
AL-108
This drug, like Rember, also addresses the problem of neurofibrillary tangles, also interfering with the formation of tangles by affecting the tau protein. However, this drug is administered as a nasal spray. Which brings up a rarely discussed aspect of drug trials: not all drug trials involve taking a pill! Some are nasal sprays, eye drops, some are even administered intravenously. The good news is results with AL-108 took far less time than Rember. Researchers reported a 62.4% improvement in memory with no side effects in only 4 months time.
Lupron (Leuprolide, Memryte)
Don’t you just love the way they name these drugs? Memryte (memory right?) or Rember (Remember?). Lupron is currently an approved drug for the treatment of advanced prostate cancer. But now they are looking at it for Alzheimer’s because it alters production of beta-amyloid in the brain. Beta-amyloid, in a nutshell, is the main material that plaques are made of. The theory is, no beta-amyloid = no plaques = no Alzheimer’s Disease.
Funny story: the connection between Lupron and Alzheimer’s was discovered accidentally, when the wife of a metastatic cancer patient who was receiving Lupron told the doctor that the drug worked well on his cancer – and his Alzheimer’s appeared to improve, too. (Wow, a doctor that listens! What a concept)
Immunoglobulins
Basically these are antibodies already in our blood. These antibodies are used by our immune system to hunt down and eliminate bacteria. This is one of those treatments that is being administered intravenously. It is still in the early stages of research, and larger studies are forming as you read this.
Rosiglitazone (Avandia)
One of the little know facts about drug approval by the FDA is that Pharmaceutical companies spend 10’s of millions of dollars bringing a drug to market. Therefore it’s safe to assume they have to be pretty confident of success before they decide to start a new drug trial. Furthermore, you can imagine that the process is complicated and technical. Let me give you an example, when they apply for a new drug approval, they have to be very specific about which disease, or condition they are going to test for. That makes sense. But occasionally after a drug comes to market it may start showing effectiveness on conditions that it was not originally intended for. But if they want doctors to legitimately prescribe their established medication for this new condition they have to start the drug trial process all over again from scratch.
Thus is the case with Lupon mentioned above (currently approved for prostrate cancer), as well as this one Avandia. Avandia is currently on the market for type 2 diabetes, in diabetics it enables their cells to use the hormone insulin more efficiently. But they now think it might affect the brain inflammation seen in Alzheimer’s patients, so they are starting new drug trials for it.
Alzheimer’s Vaccines
“Another method for targeting Alzheimer’s comes in the form of a vaccine that uses antibodies from the body’s own immune system to attack and destroy beta-amyloid and clear out plaques in the brain, or to eliminate clumps of tau protein (neurofibrillary tangles) in the brain that kill neurons responsible for memory”. Phase 3 studies are also starting this year, and they look promising. * (Oops, hold that thought, just yesterday as I was finishing this article there was story making the rounds that a prominent research physician was quoted in the press as saying that he has serious doubts that beta-amyloid is the cause of Alzheimer’s and that researchers are missing the boat, and spending a lot of time and money for nothing. Time will tell…)
Gene Therapy
This is another of those methods that have been around, getting perfected for years. It is very complicated, and involves genetically altering your own cells to produce nerve growth factor (NGF) and injecting these altered cells into the brain to slow the destruction of brain cells. They may sound creepy, but naturally produced NGF has amazing promise for many different illness and diseases. Some researchers are predicting extending the life span by decades when NGF is perfected.
Histone deacetylase (HDAC) inhibitor
Researchers are making impressive claims with this one. “This compound has the potential not only to slow degenerative memory loss, but also to reverse the process and bring back lost memories”. The HDAC inhibitor compound was first formulated at the Massachusetts Institute of Technology (MIT). “The research suggests that people with dementia might not completely lose their memories, but that the memories might be stored away somewhere that is inaccessible. The clinical trials are expected to assess whether ADAC inhibitors can safely and effectively improve cognitions and possibly reverse memory loss in humans.
This concludes the long list of drug trials that are out there for Alzheimer’s Disease. Can you imagine…this is just Alzheimer’s? I have heard of studies for just about every other major disease, and even for conditions that I did not know were a problem. For example I read about a study that was supposed to make eye-lashes grow longer and thicker. I don’t see anyone dieing of thinning eye-lashes, but I certainly see where something like that would make a fortune.
Nevertheless, if you know someone that is interested in drug trials please refer them to this site: copy and past this link: http://tinyurl.com/drugtrials.
Source: Special Report on: Combating Memory Loss (common problems and treatments) by Massachusetts General Hospital & the editors of Mind, Mood & Memory.
You want to know about drug trials, right? Before you go any further, please scroll down and read the first 2 or 3 posts that I wrote, I promise that it will answer 99% of your questions and give you the quick answer you looking for. It takes 5 minutes, so please do that now…
Affirmation Video
Now that you have read the earlier posts…what’s that? You are still reading here? No! You need to really stop, go read, then come back, ok? ok.
Great, now let’s get started. You see that box below: asking for your name, email, city and condition? That is really important if you want my help. I get a lot of requests, and people sometimes forget to say where they are writing from, or for what condition they are researching drug trials. You are ok, but other people; well they are stressed out and they sometimes forget, you know how it is.
So now I insist everyone do this. One, because you will be surprised to learn that there are hundreds of centers that do drug trials, and not just big Universities, but lot’s of private companies too. And they pick and choose what drugs they are going to test. So that’s why I need city and condition.
Name and email, that’s for me. I am happy to help people, but I am very busy and all I ask is for your contact information and I will help you for free. But don’t worry, I would never dream of sharing your information with another soul. It’s safe with me, and it goes no further than me. OK?
So now please fill out the box…even if you don’t have a condition and you just want to say hello or make a comment or ask a general question…just put n/a in the boxes for city and condition. (still do name and email).
You may not see this blog updated that often, but that’s because I answer most people personally. I rarely broadcast my answers publically. What you will see here, is the occasional product or service recommendation. Most of my readers are caregivers, and most of the caregivers I have contact with are caring for someone with Alzheimer’s Disease. Because I have over 15 years helping older adults and their caregivers, I kinda know what you are dealing with, and I know what kinda things could be a benefit for you.
One of the best free resources you use is The Alzheimer’s Association they have an amazing library of material, and your local chapter might have some grant funding to help you out with some respite care!
Been busy with other sites and other blogs, so sorry for not posting for a while. While you are waiting, please take a look at www.caregiverrelief.com or www.discoverlongevitynow.com or just send me an email.
Have you seen that commercial for “fuller eyelashes”? You know its drug because of all of the disclaimers they announce. I especially liked the one that say it may turn your iris’ brown permanately.
Anyway, thats not the point. The point is, that medication went through a drug trial! Which just goes to show that there are drug trials for everything under the sun.
In the meantime let me do some cross promotion: Finding a medication that can cure an illness or reduce the symptoms is important. But most of us have an opportunity to do something about our health, so that we do not get sick in the first place. To that end, I am happy to report a program that that teaches you the exact herbs and suppliments that you need to bullet proof your immunity (and the ones that you might be taking right now that are aging you rapidly). Please take a look. Its a jammed pack video Longevity Now Program
Donahue Vanderhider, MSG
p.s. If you are dealing with Alzheimer’s in your family, please remember to check out my website www.caregiverrelief.com